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Objectives
Title
Allergy and Asthma
Why is there an allergy epidemic?
Inverse Correlation
Graphic
Peanut Allergy
Strong and Independent
Diagram
Graphic
Experimental Asthma Model
Mechanism of Early Phase Reaction (EPR)
Cell-Derived Mediators
Central Role of Leukotrienes
Anti-Human IgE
Diagram
Diagram
Anti-IgE
Anti-IgE Improves Threshold Dose
Diagram
T helper-2 Lymphocytes
Graphic
Graphic
Graphic
Graphic
Graphic
Graphic
Graphic
Graphic
Graphic
Graphic
Chemokine Family
BALF Eosinophilia
Eotaxin mRNA
Transcriptional Regulation of Human Eotaxin
Eotaxin mRNA
Induction of Experimental Asthma
Circulating Eosinophilia Is Ablated
BALF Eosinophilia is IL-5 Dependent
Eosinophilia in the Airway Tissue
Bronchial Hyperreactivity
Graphic
Graphic
Graphic
Graphic
Graphic
CCR3 Small Molecule Antigonists
A Phae I/II Study
Beneficial Effect of Anti-IL-5
IgE-mediated Non-IgE-mediated
EGID Graphic
cincinnatichildrens.org/eosinophils
Eosinophil Accumulationin
Situation
Image
Image
Image
Image
Eosinophilic Esophagitis vs. GER
Only Intra-Pulmonary Allergen
Aspergillus-Induced Eosinophil Accumulation
Image
Image
IL-5 Gene Targeted Mice
Allergen-induced Epithelial Hyperplasia
Therapeutic Options for EE
Diagram
Chart
Summary
Flow
Rothengerg Research Program

Marc Rothenberg, M.D.

Pediatric Grand Rounds - April 8, 2003