Audio Only

Objectives
Vascular Anomalies 2004
Graphic
Nomenclature
Biologic Classification of Vascular Anomalies
Vascular Anomalies
Associated Syndromes
Vascular Anomalies
Vascular Tumors
Vascular Anomalies
Distinguishing Tumors and Malformations
Multidisciplinary Vascular Anomaly Groups
CCHMC
Hemangiomas and Vascular Malformations
Hemangiomas
Hemangioma
Graphic
Associated Anomalies or Conditions
Hemangiomas in
Image
Graphic
Graphic
Lumbosacral Hemangiomas
Multiple Cutaneous Hemangiomas
PHACES Syndrome
Hypothyroidism
Approach to Management
Treatment of Hemangiomas
Natural Regression
Indications for Immediate Treatment
Steroid Therapy
Mechanism of Action
Side Effects
Graphic
Potential Side Effects
Corticosteroid-Induced Regression
Interferon
Interferon-Review of the Literature
Neurotoxicity
Alfa-Interferon Induced Regression
Vincristine Treatment for Complicated Hemangiomas
Vincristine Therapy for Complicated Hemangiomas
Vincristine Response
Conclusions
Surgical Therapy for Hemangiomas
Image
Graphic
Kasabach-Merritt Phenomenon
The Enlarging Lesion
Kaposiform Hemangioendotheliomas and Tufted Angiomas
Graphic
Graphic
KHE and Tufted Angioma
Vascular Malformations
Capillary Malformations
Facial CM: Laser Treatment
Facial CM: Excision and Resurfacing
Venous Malformations
Venous Malformation: Sclerotherapy
Venous Malformation:
Arteriovenous
Arteriovenous Malformations
Fairly well accepted that early excision of an AVM provides an optimal outcome
Lymphatic Malformations
Lymphatic Malformation: Surgical Resection
Combined Vascular Malformations
Capillary
CLVM Progression
Indications for Medical Management
Medical Treatment Options
Venous/Veno-Lymphatic Malformations
Non-Pharmacological Treatment Options
Conclusion
Judah Folkman, MD
Angiogenesis Timeline
Image
Vascular Anomalies
AVM Progression
CM Progression
Vascular Malformations
Research Approaches
Graphic
Increased Incidence of Matrix Metalloproteinases in the Urine of Cancer Patients
Matrix Metalloproteinases (MMPs)
Graphic
Urine from
Central Aims of Study
Study Population (n=292)
Data Collected for Each Patient
Disease Extent
Graphic
Disease Activity
Graphic
Graphic
Graphic
Graphic
Findings
New ELISA Findings
Tissue Microarray Studies
Data
Data
Immunohistochemistry and In Situ Hybridization
Summary
Special Thanks

Denise Adams, M.D., Jennifer Marler, M.D.

Vascular Anomalies 2004